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Metabolic Osteoarthritis

Metabolic Osteoarthritis

What is Adiposano®?

Adiposano® includes the active ingredients used in the European product called Oralvisc® – an innovative Glycosaminoglycan formulation based on a patented composition of hyaluronic acid and dermatan sulphate) which contributes to the normal function of cartilage and metabolism. The active ingredients in Adiposano® have been clinically shown to reduce inflammation in synovial fluid and thereby reduce the pain associated with moderate to severe metabolic osteoarthritis.3

Adiposano® is indicated for obese individuals (BMI≥30) who are approaching a metabolic syndrome state and who exhibit characteristics of excess white adipose tissue syndrome (eWATS). Adiposano® works by modulating the release of adipokines from fatty tissue to help restore healthy metabolic function.

Metabolic OA Pain Management4,5

Over the course of 90 days, supplementation with Oralvisc® (GAG 80mg, 2 capsules daily) in obese patients has been shown to improve joint function and reduce knee/joint pain. The relationship of reduced bradykinin and decreased joint pain (in the group taking Oralvisc®) is consistent with previous studies.

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

WOMAC Index

Patients treated with Adiposano® for 3 months should WOMAC Index experience significant improvements in joint function.

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

Over the course of 90 days, supplementation with the active ingredients in Adiposano® (GAG 80mg, 2 Capsules daily) SIGNIFICANTLY IMPROVED JOINT FUNCTION IN OA KNEE PATIENTS when compared to placebo.

Metabolic OA Support5
Over the course of 90 days, supplementation with Oralvisc® (GAG 80mg, 2 capsules daily) significantly reduced the pro-inflammatory adipokine Leptin in both serum and synovial fluid of OA knee patients when compared to placebo.

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

LEPTIM SERUM

SYNOVIAL FLUID

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

An Oral Preparation Containing Hylauronic acid (Oralvisc®)
Can Reduce Osteoarthritis Knee Pain and Serum and Synovial Fluid Bradykinin

REFERENCES
1 Issa, RA, et al. Pathobiol Aging Age Relat Dis. 2012 2:17470.
2 Gualilio et al. Osteoarthritis Cartilage 2007 15:857-60.
3 Reynes, B etal, J Funct Foods, 2016 26:350-362.
4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan;35(1):43-52
6 Yamada S., et.al; Current Drug Discovery Technologies,2008,5,289-301