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Metabolic Osteoarthritis

The Link Between Obesity and OA Knee Pain

Excess White Adipose Tissue (eWAT) increase weight on the joints and releases pro-inflammatory cytokines (like leptin).  Likewise, OA creates metabolic changes such as increase de novo lipogenesis and additional pro-inflammatory cytokines being released into synovial fluid. This creates discomfort and restricted mobility in the joints due to increased inflammation.

How Adipokines Affect Obesity The Role of Leptin in Obesity

Leptin is a key type of adipokine used in the body’s metabolic functions. The release of leptin inhibits hunger in order to help the body maintain an optimal energy balance. When the body is at rest, leptin is : released to discourage the consumption of unnecessary calories. When the body is active, leptin is counteracted by another protein to induce hunger.

Leptin resistance is a common condition in obese persons. The excess white adipose tissue (eWAT) activates and contributes excess hormones into circulation. Eventually, leptin receptors are no longer able to accurately decipher these signals. Those patients who suffer from leptin resistance often may not feel full enough, regardless of how many calories they consume. If not expended through exercise, those excess calories are stored as fat, creating additional adipose tissue.

Increased leptin levels are also associated with severe knee injuries. Medical professionals are now using elevated leptin levels to predict the possibility of early post-traumatic knee osteoarthritis. This condition affects younger people who have previously suffered a knee injury. Even after damaged tissues are healed, patients can still experience severe joint pain.

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52
4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52
4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52
4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

Metabolic OA Pain Management

Over the course of 90 days, supplementation with Adiposano® (GAG, 80mg – two capsules daily) in obese patients has been shown to improve joint function and reduce knee/ joint pain. The relationship of reduced bradykinin and decreased joint pain (in the active group) is consistent with previous studies.

The Link Between Obesity and OA Knee Pain

Excess White Adipose Tissue (eWAT) increase weight on the joints and releases pro-inflammatory cytokines (like leptin).  Likewise, OA creates metabolic changes such as increase de novo lipogenesis and additional pro-inflammatory cytokines being released into synovial fluid. This creates discomfort and restricted mobility in the joints due to increased inflammation.

4 Nelson, et al. OARSI Poster, 2013 ORS Annual Meeting, data on file Bioberica, SA
5 Nelson, et al. Rheumatol Int. 2015 Jan; 35(1):43-52

How does Adiposano® work?

The mechanism of action of Adiposano has not been completely elucidated. Research suggests Adiposano® can inhibit adipogenesis (the creation of new fat cells), decrease pro-inflammatory cytokines, and decrease inflammation both systemically and in the synovial fluid.  We believe that Adiposano® works block or restrict an upstream mechanism (perhaps CD44) which prevents a broad cascade of inflammatory response.

The Link Between Obesity and OA Knee Pain

Excess White Adipose Tissue (eWAT) increase weight on the joints and releases pro-inflammatory cytokines (like leptin).  Likewise, OA creates metabolic changes such as increase de novo lipogenesis and additional pro-inflammatory cytokines being released into synovial fluid. This creates discomfort and restricted mobility in the joints due to increased inflammation.

Here are some helpful brochures and One Sheets to provide more information for you and your doctor.

Click to print a PDF of any of the following choices:

Affected Inflammatory Markers

An Adiposano® detail brochure page showing affected the inflammatory markers.

White Paper

A PDF of a White Paper to explain the Metabolic OsteoArthritis of Adiposano® for your doctor.

Case Study

A case study done on Adiposano® / Metabolic Benefits

FAX Order Form

An Adiposano® fax order form that your office may use.